Dichloromethane → 6,7-Dimethoxy-1-methyl-2-phenyl-1H-quinazolin-4-one

HRID 557127Notes

Reaction equation

HRID 557127 reaction equation
[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[CH:10][C:6]([C:7]([NH2:9])=[O:8])=[C:5]([NH:14][CH3:15])[CH:4]=1.C(Cl)(=O)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.Cl[CH2:26]Cl>>[CH3:13][O:12][C:11]1[CH:10]=[C:6]2[C:5](=[CH:4][C:3]=1[O:2][CH3:1])[N:14]([CH3:26])[C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[N:9][C:7]2=[O:8]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 7412Benzoyl chlorideHCID 669914734,5-Dimethoxy-2-(methylamino)benzamide

Product 1

HCID 669910066,7-Dimethoxy-1-methyl-2-phenyl-1H-quinazolin-4-one

Procedure

2.00 g (9.51 mmol) 4,5-Dimethoxy-2-methylamino-benzamide were dissolved in 20 ml dichloromethane and 4.01 g (3.31 ml, 28.5 mmol) benzoyl chloride are added. The mixture was boiled for 90 min. After filtration the residue was dissolved in trichloromethane and saturated sodium bicarbonate solution. The organic solution was dried over magnesium sulfate and evaporated under vacuum.

Workup

  1. filtrationAfter filtration the residue
  2. dissolutionwas dissolved in trichloromethane
  3. dry with materialThe organic solution was dried over magnesium sulfate
  4. customevaporated under vacuum

Sources & evidence

ORD record
ord-f5337b2a9c614703a958686c7c032835
Source dataset
uspto-grants-2011_11
Patent number
US08058431B2

Reaction notes

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