Methyl iodide → 6,7-Dimethoxy-1-methyl-4-methylsulfanyl-2-phenyl-quinazolin-1-ium iodide

HRID 557129Notes

Reaction equation

HRID 557129 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]([CH3:15])[C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[N:7][C:6]2=[S:22].[I:23][CH3:24]>>[I-:23].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N+:9]([CH3:15])=[C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[N:7]=[C:6]2[S:22][CH3:24]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 866355306,7-Dimethoxy-1-methyl-2-phenyl-1H-quinazolin-4-thione

Product 1

HCID 669913456,7-Dimethoxy-1-methyl-4-methylsulfanyl-2-phenyl-quinazolin-1-ium iodide

Procedure

1.00 g (3.20 mmol) 6,7-Dimethoxy-1-methyl-2-phenyl-1H-quinazolin-4-thione was slowly added to 5 ml (80 mmol) iodomethane at 0° C. and stirred for 1 h at room temperature. The solution was filtrated and the residue washed with ethyl ether and dichloromethane.

Workup

  1. filtrationThe solution was filtrated
  2. washthe residue washed with ethyl ether and dichloromethane

Sources & evidence

ORD record
ord-29a46963b21a4491bf07eb420f74de6a
Source dataset
uspto-grants-2011_11
Patent number
US08058431B2

Reaction notes

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