Chloroform → 6-Methoxy-1-methyl-2-phenyl-1H-quinazolin-4-one

HRID 557133Notes

Reaction equation

HRID 557133 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:12][CH3:13])=[C:7]([CH:11]=1)[C:8]([NH2:10])=[O:9].C(Cl)(=O)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.Cl[CH:24](Cl)Cl>>[CH3:1][O:2][C:3]1[CH:11]=[C:7]2[C:6](=[CH:5][CH:4]=1)[N:12]([CH3:24])[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[N:10][C:8]2=[O:9]

Participants

4

Reactant 3

HCID 6212ChloroformHCID 7412Benzoyl chlorideHCID 669916645-Methoxy-2-methylamino-benzamide

Product 1

HCID 669907996-Methoxy-1-methyl-2-phenyl-1H-quinazolin-4-one

Procedure

1.00 g (5.55 mmol) 5-Methoxy-2-methylamino-benzamide were dissolved in 25 ml trichloromethane and 2.34 g (1.93 ml, 16.6 mmol) benzoyl chloride were added. The mixture was boiled for 90 min. After filtration the residue was dissolved in trichloromethane and saturated sodium bicarbonate solution. The organic solution was dried over magnesium sulfate and evaporated under vacuum.

Workup

  1. filtrationAfter filtration the residue
  2. dissolutionwas dissolved in trichloromethane
  3. dry with materialThe organic solution was dried over magnesium sulfate
  4. customevaporated under vacuum

Sources & evidence

ORD record
ord-17071fecd7ff4903b8121cd23762b920
Source dataset
uspto-grants-2011_11
Patent number
US08058431B2

Reaction notes

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