反应详情

1.70 g (10.9 mmol) 3-Methylamino-thiophene-2-carboxylic acid amide were dissolved in 20 ml trichloromethane and 3.82 g (3.16 ml, 22.2 mmol) benzoyl chloride were added. The mixture was boiled for 90 min. After filtration the residue was dissolved in trichloromethane and washed with saturated sodium bicarbonate solution. The organic solution was dried over magnesium sulfate and evaporated under vacuum. The crude product was purified by column chromatography on silica, eluent dichloromethane/methanol 95/5.

1. filtrationAfter filtration the residue
2. dissolutionwas dissolved in trichloromethane
3. washwashed with saturated sodium bicarbonate solution
4. dry with materialThe organic solution was dried over magnesium sulfate
5. customevaporated under vacuum
6. customThe crude product was purified by column chromatography on silica, eluent dichloromethane/methanol 95/5