HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lawesson's reagent → 1-Methyl-2-phenyl-1H-thieno(3,2-d)pyrimidine-4-thione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 1-Methyl-2-phenyl-1H-thieno(3,2-d)pyrimidine-4-one | HCID 66991244 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-Methyl-2-phenyl-1H-thieno(3,2-d)pyrimidine-4-thione | HCID 86635532 | — |
Reaction Steps
2.10 g (8.67 mmol) 1-Methyl-2-phenyl-1H-thieno(3,2-d)pyrimidine-4-one and 3.51 g (8.67 mmol) Lawesson's reagent (C14H14O2P2S4, Fluka) were dissolved in 40 ml toluene. The reaction mixture was boiled for 3 h. After evaporation the residue was further purified by column chromatography with silica, eluent dichloromethane/acetone 95/5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058431B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-3fc6b8c30b9441c4b4fa1dfa546260b6 |
| Source note | uspto-grants-2011_11 |