反应详情

Add N-bromosuccinimide (63.16 g, 354.9 mmol) as a solution in anhydrous acetonitrile (480 mL) to a suspension of 5H-furo[3,2-c]pyridin-4-one (36.9 g, 273 mmol) in anhydrous acetonitrile (740 mL) at 0° C. over 1 hour. Warm to room temperature, add anhydrous methyl alcohol (1.5 L) and stir at room temperature for 18 hours. Quench with water (20 ml) and saturated sodium bicarbonate (20 mL), concentrate to a volume of 1.3 liters, and pour into water (1.3 L). Collection of the precipitate by filtration and drying (vacuum oven 2 days 40-60° C.) gives the title compound as an off-white solid.

1. customQuench with water (20 ml) and saturated sodium bicarbonate (20 mL)
2. concentrationconcentrate to a volume of 1.3 liters
3. additionpour into water (1.3 L)
4. customCollection of the precipitate
5. filtrationby filtration
6. customdrying (vacuum oven 2 days 40-60° C.)