HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 557186Generated: October 30, 2026
3,4-dihydro-2H-pyran → HCID 17985424, compound
https://huagongshe.com/reaction/557186
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | HCID 17985866 | HCID 17985866 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 17985424 | HCID 17985424 | — |
Reaction Steps
Combine 7-bromo-5-hydroxybenzofuran (5.0 g, 0.0235 mol) with pyridinium para-toluenesulfonate (0.59 g, 0.1 equivalent) and dissolve in 60 mL dichloromethane under nitrogen. Add via syringe 3,4-dihydro-2H-pyran (3.2 mL, 1.5 equivalents) and stir at 20° C. overnight. Dilute with dichloromethane then extract with 1N sodium hydroxide and wash with brine. Dry over sodium sulfate, filtered, and then concentrate to afford the title compound as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08058425B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-1cde466f39b1429281cc6946b339c1b9 |
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| Source note | uspto-grants-2011_11 |
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