HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 557191Generated: October 29, 2026
Ammonia → Imidazo(1,2-a)pyridine-3-acetamide
https://huagongshe.com/reaction/557191
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethyl 2-(imidazo[1,2-a]pyridin-3-yl)acetate | HCID 11171725 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Imidazo(1,2-a)pyridine-3-acetamide | HCID 89059 | — |
Reaction Steps
Bubble ammonia through a solution of (imidazo[1,2-a]pyridin-3-yl)acetic acid ethyl ester (10.0 g, 48.96 mmol) in methanol (30 ml) at 0° C. Heat the reaction mixture in a sealed tube at 100° C. for 2 hours. Concentrate the reaction mixture under reduced pressure. Triturate with ethyl acetate to give the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08058425B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-da177803d75041be8e2d7c569a476cd5 |
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| Source note | uspto-grants-2011_11 |
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