Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Iodide → 2-Iodo-1-morpholin-4-yl-ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Morpholine, 4-(chloroacetyl)- | HCID 74040 | — |
| 용매 | Methyl Ethyl Ketone | HCID 6569 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-Iodo-1-morpholin-4-yl-ethanone | HCID 11265309 | 86.1% |
반응 단계
Dissolve 1-chloro-2-oxo-2-(morpholin-4-yl)ethane (7.0 g, 42.8 mmol) and sodium iodide (8.0 g, 53.4 mmol) in 2-butanone (150 mL) and reflux for 3 hours under nitrogen. Dilute with ethyl acetate (200 mL), filter, concentrate under reduced pressure and chromatograph on flash silica using neat ethyl acetate to obtain 9.4 g (86%) of the title compound as a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08058425B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-994137f221d641ddab06c2229a5332d0 |
| 출처 메모 | uspto-grants-2011_11 |