Thionyl Chloride → 2-AMino-N-(2,3-dihydro-benzo[1,4]dioxin-6-ylMethyl)-acetaMide

Participants

Reaction Steps

Dissolve (2,3-Dihydrobenzo[1,4]dioxin-5-yl)methanol (1.8 g, 10.8 mmol) in dichloromethane (15 mL). Add neat thionyl chloride (2 mL, 27.4 mmol) dropwise to the stirring reaction mixture at 25° C. under nitrogen. Stir the reaction for 15 minutes and concentrate under reduced pressure to obtain 2.0 g (100%) of the desired compound as a yellow oil.

Provenance & Evidence