反应详情

温度

20 °C

Dissolve (5-fluoro-2-nitrophenyl)methanol (13.92 g, 81.08 mmol) in dichloromethane (284 mL). Add 4 Å molecular sieves (73 g) and pyridinium dichromate (36.58 g, 97.3 mmol). Stir the mixture at 20° C. for 6 hours. Filter the crude reaction mixture through a short silica gel column. Remove the solvent under reduced pressure and purify the residue by flash chromatography (silica gel, 10-20% ethyl acetate/hexane) to obtain 9.43 g (69%) of title compound as colorless oil.

1. filtrationFilter the crude
2. customreaction mixture through a short silica gel column
3. customRemove the solvent under reduced pressure
4. custompurify the residue by flash chromatography (silica gel, 10-20% ethyl acetate/hexane)