反应详情

To a mixture of (4-(pyridin-2-yloxymethyl)-phenyl)methanol described in Preparation Example 1-3-1 (1.9 g, 8.6 mmol) and methylene chloride (30 mL) was added manganese dioxide (15 g, 17 mmol) at room temperature, which was stirred overnight at this temperature. The reaction mixture was filtered through a celite bed, and the solvent thereof was evaporated under a reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:heptane=1:4) to obtain the title compound (770 mg).

1. filtrationThe reaction mixture was filtered through a celite bed
2. customthe solvent thereof was evaporated under a reduced pressure
3. customThe residue was purified by silica gel column chromatography (ethyl acetate:heptane=1:4)