Ethanol → HCID 86624480, compound

Participants

Reaction Steps

To a mixture of methyl 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate described in Preparation Example 2-1-1 (19.9 g) and ethanol (300 mL) were sequentially added sodium methoxide (14.2 mL, 28% methanol solution), water (1.3 mL), tetrahydrofuran (100 mL) at 0° C, which was stirred at room temperature for one hour. To the reaction mixture was added diethyl ether (200 mL), and the precipitated solids were filtered to obtain the title compound (14.3 g).

Provenance & Evidence