Acetic Acid → HCID 59841576, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of sodium 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate described in Preparation Example 2-1-2 (9.95 g), toluene (200 mL), water (120 mL) and acetic acid (16 mL) was stirred at 73° C for 90 minutes. The reaction mixture was allowed to room temperature, to the reaction mixture was added ethyl acetate, and extracted, and then the organic layer was separated, washed with saturated sodium chloride water, and dried over anhydrous magnesium sulfate. The solvent thereof was evaporated under a reduced pressure to obtain the title compound (6.82 g).

Provenance & Evidence