Water → HCID 72576087, compound

Participants

Reaction Steps

To a mixture of hydroxylamine sulfate (19.7 g) and water (250 mL) was added an aqueous solution of 1N sodium hydroxide (240 mL) at 0° C, which was stirred at the same temperature for 15 minutes. Then, at the same temperature, to the reaction mixture was added a mixture of (4-(pyridin-2-yloxymethyl)-phenyl)-acetaldehyde described in Preparation Example 2-1-3 (27.3 g) and methanol (250 mL) dropwise, which was stirred overnight at room temperature. The precipitated solids were filtered to obtain the title compound (20.3 g) as a mixture of E isomer and Z isomer.

Provenance & Evidence