Methanesulfonic Acid → HCID 25070763, compound

Participants

Reaction Conditions

Reaction Steps

To 3-(3-(4-(pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridin-2-yl amine (500 mg) was added methanol (1.5 mL), and under heat-stirring at 40° C, to this suspension was added a solution of methanesulfonic acid (96.5 μL) in methanol (0.5 mL) dropwise, which turned into a solution. After stirring at 40° C for 10 minutes and seeding, crystals precipitated. After stirring at 40° C for 20 minutes, tert-butyl methyl ether (10 mL) was added thereto dropwise at the same temperature over one hour, then, after slow cooling, stirring was carried out at 23° C for 15 minutes. The precipitated crystals were filtered and dried to obtain the title compound (629 mg) as a slightly yellow crystal.

Provenance & Evidence