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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 557289Generated: October 30, 2026

Maleic Acid → HCID 25071085, compound

https://huagongshe.com/reaction/557289

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMaleic AcidHCID 444266—
ReactantE-1210HCID 16719049—
SolventMethanolHCID 887—
SolventEthyl AcetateHCID 8857—
ProductHCID 25071085HCID 2507108568.5%

Reaction Conditions

Temperature0 °C

Reaction Steps

3-(3-(4-(Pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridin-2-yl amine (150 mg) was dissolved in methanol (2 mL) and ethyl acetate (2 mL), and maleic acid (48.6 mg) was added thereto. The solvent was concentrated under a reduced pressure, to the residue was added ethanol (10 mL), and dissolved by heating. Then, the solution was cooled to 0° C to be solidified. The solids were filtered to obtain the title compound (136 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08058444B2
Source datasetuspto-grants-2011_11
ORD IDord-3e539421b13243d5a17a99eb7f37c517
Source noteuspto-grants-2011_11