Citric Acid → HCID 25070440, compound

Participants

Reaction Conditions

Reaction Steps

To 3-(3-(4-(pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridin-2-yl amine (1 g) and citric acid (564 mg) was added methanol (3 mL), and the suspension was stirred at 30 to 35° C, to turn it into a solution. Under stirring at 30° C, after adding tert-butyl methyl ether (3 mL) dropwise over 15 minutes to this solution and seeding, crystals precipitated. After stirring at 30° C for 10 minutes, tert-butyl methyl ether (15 mL) was added at the same temperature for one hour, and after slow cooling, mixture was stirred at 23° C for two hours. The precipitated crystals were filtered and dried to obtain the title compound (1.34 g) as a white crystal.

Provenance & Evidence