HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloronicotinoyl chloride → 1-Boc-4-(3-[(2-chloro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloronicotinoyl chloride | HCID 2774541 | — |
| Reactant | 1-Boc-4-(3-amino-5-trifluoromethyl-phenoxy)piperidine | HCID 21959419 | — |
| Reactant | 1-Boc-4-[3-[(2-fluoro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidine | HCID 21959521 | — |
| Product | 1-Boc-4-(3-[(2-chloro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidine | HCID 21959647 | — |
Reaction Steps
1-Boc-4-{3-[(2-chloro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidine was prepared from 1-Boc-4-(3-amino-5-trifluoromethyl-phenoxy)-piperidine and 2-chloropyridine-3-carbonyl chloride by a procedure similar to that described in the preparation of 1-Boc-4-{3-[(2-fluoro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058445B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-d829e64c17034f18b9408df2241464f0 |
| Source note | uspto-grants-2011_11 |