HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 557305Generated: October 26, 2026
Hydrochloric Acid → 3-(3-(Piperidin-1-yl)propyl)-5-(trifluoromethyl)benzenamine
https://huagongshe.com/reaction/557305
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-[3-(3-Piperidin-1-yl-propyl)-5-trifluoromethyl-phenyl]-acetamide | HCID 21959446 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(3-(Piperidin-1-yl)propyl)-5-(trifluoromethyl)benzenamine | HCID 21959527 | — |
Reaction Steps
N-[3-(3-Piperidin-1-yl-propyl)-5-trifluoromethyl-phenyl]-acetamide (1.33 g) was dissolved in EtOH (40 ml) and 12 N HCl (40 ml) was added. After stirring overnight at 70° C. and RT, the mixture was concentrated in vacuo, affording 3-(3-piperidin-1-yl-propyl)-5-trifluoromethyl-phenylamine as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08058445B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-59162f4b22464dc4931060ef7a4ec675 |
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| Source note | uspto-grants-2011_11 |
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