N-[3-(3-Morpholin-4-yl-propyl)-5-trifluoromethyl-phenyl]-acetamide → 3-(3-Morpholinopropyl)-5-(trifluoromethyl)benzenamine

HRID 557308Notes

Reaction equation

HRID 557308 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][C:10]2[CH:11]=[C:12]([NH:20]C(=O)C)[CH:13]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:15]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.N1(CCCC2C=C(N)C=C(C(F)(F)F)C=2)CCCCC1>>[N:1]1([CH2:7][CH2:8][CH2:9][C:10]2[CH:11]=[C:12]([NH2:20])[CH:13]=[C:14]([C:16]([F:17])([F:19])[F:18])[CH:15]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 21959489N-[3-(3-Morpholin-4-yl-propyl)-5-trifluoromethyl-phenyl]-acetamideHCID 219595273-(3-(Piperidin-1-yl)propyl)-5-(trifluoromethyl)benzenamine

Product 1

HCID 219594313-(3-Morpholinopropyl)-5-(trifluoromethyl)benzenamine

Procedure

3-(3-Morpholin-4-yl-propyl)-5-trifluoromethyl-phenylamine was prepared from N-[3-(3-morpholin-4-yl-propyl)-5-trifluoromethyl-phenyl]-acetamide similar to that described in the preparation of 3-(3-piperidin-1-yl-propyl)-5-trifluoromethyl-phenylamine.

Sources & evidence

ORD record
ord-eb24b85d4c5c4813a77cc36089cc9fbd
Source dataset
uspto-grants-2011_11
Patent number
US08058445B2

Reaction notes

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