1-(2-Chloroethyl)piperidine → 1-[2-(5-Nitro-2-pentafluoroethyl-phenoxy)-ethyl]-piperidine

HRID 557323Notes

Reaction equation

HRID 557323 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:11]([F:17])([F:16])[C:12]([F:15])([F:14])[F:13])=[C:8]([OH:10])[CH:9]=1)([O-:3])=[O:2].Cl[CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1.C(C1C=CC([N+]([O-])=O)=CC=1OCCN1CCCCC1)(C)(C)C>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:11]([F:16])([F:17])[C:12]([F:13])([F:14])[F:15])=[C:8]([CH:9]=1)[O:10][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)([O-:3])=[O:2]

Participants

4

Reactant 3

HCID 748271-(2-Chloroethyl)piperidineHCID 17756181Phenol, 5-nitro-2-(1,1,2,2,2-pentafluoroethyl)-HCID 219595061-[2-(2-Tert-butyl-5-nitro-phenoxy)-ethyl]-piperidine

Product 1

HCID 219593461-[2-(5-Nitro-2-pentafluoroethyl-phenoxy)-ethyl]-piperidine

Procedure

1-[2-(5-Nitro-2-pentafluoroethyl-phenoxy)-ethyl]-piperidine was prepared from 5-nitro-2-pentafluoroethylphenol and 1-(2-chloroethyl)piperidine by a procedure similar to that described in the preparation of 1-[2-(2-tert-butyl-5-nitro-phenoxy)-ethyl]-piperidine.

Sources & evidence

ORD record
ord-de8a7b6d9b08428fbb0d1f92a54e3efb
Source dataset
uspto-grants-2011_11
Patent number
US08058445B2

Reaction notes

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