HCID 10222542, compound → HCID 9969044, compound

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Reaction Steps

{6-Chloro-5-fluoro-2-[(4-pyridylmethyl)amino](3-pyridyl)}-N-[4-(methylethyl)phenyl]carboxamide (50 mg, 0.125 mmol, from Example 66) dissolved in EtOH (10 mL) with TEA (0.5 mL) and suspended with Pd/C (10%, 5 mg). The mixture was stirred at RT under a H2 balloon for 45 min. The mixture was filtered through a layer of Celite® and the filtrate was concentrated in vacuo. The residue was partitioned between CH2Cl2 and aq. NaHCO3 (sat.). The organic solution was dried over Na2SO4 and concentrated in vacuo to give the title compound. MS: 365 (M+1). Calc'd. for C21H21FN4O−364.42.

Provenance & Evidence