HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 557348Generated: October 25, 2026
Ammonium Chloride → Tert-butyl 4-aminophenethylcarbamate
https://huagongshe.com/reaction/557348
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Tert-butyl N-[2-(4-nitrophenyl)ethyl]carbamate | HCID 10264884 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | Tert-butyl 4-aminophenethylcarbamate | HCID 382207 | — |
Reaction Steps
A mixture of (tert-butoxy)-N-[2-(4-nitrophenyl)ethyl]-carboxamide (570 mg, 2.15 mmol, Step A), iron powder (602 mg, 10.75 mmol) and NH4Cl (82 mg, 1.5 mmol) in EtOH (6 mL) and H2O (6 ml) was stirred for 4 h at 80° C. Filtration and concentration gave the crude compound, which was used in next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08058445B2 |
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| Source dataset | uspto-grants-2011_11 |
|---|
| ORD ID | ord-882581988480452a9e786ff4ef262e6d |
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| Source note | uspto-grants-2011_11 |
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