HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 1-Methyl-4-piperidinemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 4-Piperidinemethanol | HCID 420771 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-Methyl-4-piperidinemethanol | HCID 271971 | — |
Reaction Steps
To a solution of 4-piperidylmethanol (1.0 g, 8.7 mmol) and HCHO (2 mL, 25 mmol, 37% in H2O) in CH3CN was added NaCNBH3 (0.5 g, 12.5 mmol). The resulting mixture was stirred for 1 h and filtered. The filtrate was concentrated and the residue was distilled (105° C., 40 torr) to give the title intermediate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058445B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-0502c97f6746462a80cb192c0d09bb50 |
| Source note | uspto-grants-2011_11 |