HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → N-(4-Pentafluoroethyl-phenyl)-2-[(pyrimidin-4-ylmethyl)-amino]-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Pyrimidine-4-carboxaldehyde | HCID 11412355 | — |
| Reactant | 2-Amino-N-(4-pentafluoroethyl-phenyl)-nicotinamide | HCID 22249392 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | N-(4-Pentafluoroethyl-phenyl)-2-[(pyrimidin-4-ylmethyl)-amino]-nicotinamide | HCID 22249292 | — |
Reaction Steps
2-Amino-N-(4-pentafluoroethyl-phenyl)-nicotinamide (180 mg), TSOH (40 mg) and a solution of pyrimidine-4-carboxaldehyde in DMSO (10 ml) were stirred at 60 C for 6 h. Treated with NaBH4 (200 mg) and stirred for 2 h at RT. MS (ES+): 566.3 (M+H)+; Calc'd for C26H28F5N7O2−565.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058445B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-0c37f431f6364dbb91714ef33da94843 |
| Source note | uspto-grants-2011_11 |