2-Methyl-4-oxo-4H-chromene-8-carbaldehyde → HCID 66991397, compound

HRID 557418Notes

Reaction equation

HRID 557418 reaction equation
[CH3:1][C:2]1[O:3][C:4]2[C:9]([C:10](=[O:12])[CH:11]=1)=[CH:8][CH:7]=[CH:6][C:5]=2[CH:13]=O.[C:15]([O:21][CH:22]1[CH2:25][CH2:24][CH2:23]1)(=[O:20])[CH2:16][C:17]([CH3:19])=[O:18]>>[CH3:1][C:2]1[O:3][C:4]2[C:9]([C:10](=[O:12])[CH:11]=1)=[CH:8][CH:7]=[CH:6][C:5]=2[CH:13]=[C:16]([C:17](=[O:18])[CH3:19])[C:15]([O:21][CH:22]1[CH2:23][CH2:24][CH2:25]1)=[O:20]

Participants

3

Reactant 2

HCID 133748832-Methyl-4-oxo-4H-chromene-8-carbaldehydeHCID 20189390Cyclobutyl 3-oxobutanoate

Product 1

HCID 66991397HCID 66991397, compound

Procedure

The title compound is prepared in analogy to example 25 (stage 25a) starting from 2-methyl-4-oxo-4H-chromene-8-carbaldehyde (2 g, 10.62 mmol) and cyclobutyl acetoacetate (1.66 g, 10.62 mmol). 3.4 g (98% of theory) of the title compound are obtained as an E/Z isomer mixture.

Workup

  1. customThe title compound is prepared in analogy to example 25 (stage 25a)

Sources & evidence

ORD record
ord-f922946af9934939ac80684adc7b88d4
Source dataset
uspto-grants-2011_11
Patent number
US08058447B2

Reaction notes

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