HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetoacetate → Ethyl 2-[(6-fluoro-2-methyl-4-oxo-4H-chromen-8-yl)methylene]-3-oxobutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | 6-Fluoro-2-methyl-4-oxo-4H-1-benzopyran-8-carbaldehyde | HCID 57828650 | — |
| Product | Ethyl 2-[(6-fluoro-2-methyl-4-oxo-4H-chromen-8-yl)methylene]-3-oxobutanoate | HCID 66991191 | — |
Reaction Steps
The title compound is prepared in analogy to example 25 (stage 25a) starting from 6-fluoro-2-methyl-4-oxo-4H-chromene-8-carbaldehyde (2.18 g, 10.62 mmol) and ethyl acetoacetate (1.33 g, 10.62 mmol). 3.30 g (98% of theory) of the title compound are obtained as an E/Z isomer mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058447B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-9ce9a6eda12745f59bfd59ad0e46452c |
| Source note | uspto-grants-2011_11 |