Acetic Acid → HCID 66991936, compound

Participants

Reaction Steps

32 mg (0.137 mmol) of 2-methyl-5-nitro-4-oxo-4H-chromene-8-carbaldehyde are dissolved with 19.7 mg (0.137 mmol) of isopropyl acetoacetate, 11.26 mg (0.137 mmol) of 3-aminocrotononitrile and 8.24 mg (0.137 mmol) of acetic acid in 3 ml of 2-propanol and heated under reflux under argon for 6 h. The solvent is removed in vacuo, and the residue is purified by preparative HPLC. 13 mg (22.3% of theory) of the title compound are obtained as a yellow solid.

Provenance & Evidence