HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 66991480, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Isopropyl acetoacetate | HCID 68329 | — |
| Reactant | (2Z)-3-Amino-2-butenenitrile | HCID 5325263 | — |
| Reactant | 8-Formyl-2-methyl-4-oxo-4H-1-benzopyran-5-carbonitrile | HCID 57828613 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 66991480 | HCID 66991480 | — |
Reaction Steps
21 mg (0.09 mmol) of 8-formyl-2-methyl-4-oxo-4H-chromene-5-carbonitrile are dissolved with 14 mg (0.09 mmol) of isopropyl acetoacetate, 8 mg (0.09 mmol) of 3-aminocrotononitrile and 6 mg (0.09 mmol) of acetic acid in 2 ml of 2-propanol and heated under reflux under argon for 6 h. The solvent is removed in vacuo, and the residue is purified by preparative HPLC. 8.8 mg (22% of theory) of the title compound are obtained as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058447B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-8764b67b1af140a2b5b3c71e1ddfdce5 |
| Source note | uspto-grants-2011_11 |