HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylamine → Propyl (4S)-5-cyano-2,6-dimethyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-1,4-dihydropyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | Propyl 5-cyano-2,6-dimethyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-1,4-dihydropyridine-3-carboxylate | HCID 15978970 | — |
| Reactant | Isohexane ethanol | HCID 86593186 | — |
| Product | Propyl (4S)-5-cyano-2,6-dimethyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-1,4-dihydropyridine-3-carboxylate | HCID 66991979 | — |
Reaction Steps
430 mg (1.13 mmol) of racemic propyl 5-cyano-2,6-dimethyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-1,4-dihydropyridine-3-carboxylate (example 4) are separated into the enantiomers by preparative HPLC on a chiral phase [column: Chiralpak AD-H, 250 mm×4.6 mm; eluent: isohexane/ethanol 3:1 (v/v)+0.2% diethylamine; flow rate: 1 ml/min; UV detection: 220 nm]:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058447B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-28b1b3b55e15489caabb634ff59bfff8 |
| Source note | uspto-grants-2011_11 |