反应详情

To 6.0 g of 2-amino-5-(N-formyl-N-methylamino-methyl)-benzoic acid, there was added 30 mL of pyridine and then 11.1 mL of ethyl chloroformate was dropwise added to the mixture while ice-cooling the same. After the elapse of a night, 20 mL of water was dropwise added to the mixture to separate out a solid material, the solid was then isolated through filtration under reduced pressure and washed with 20 mL of water. Then the solid thus separated was dried under reduced pressure to give 3.97 g of the intended compound as a white solid.

1. temperaturecooling the same
2. customto separate out a solid material
3. customthe solid was then isolated through filtration under reduced pressure
4. washwashed with 20 mL of water
5. customThen the solid thus separated
6. customwas dried under reduced pressure