関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 4-Chloro-7-methoxyquinoline-6-carboxamide | HCID 22936418 | — |
| 反応物 | ME-92 | HCID 23135084 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Lenvatinib | HCID 9823820 | 88% |
反応手順
To dimethylsulfoxide (20 mL) were added 7-methoxy-4-chloro-quinoline-6-carboxamide (0.983 g), 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea (1.13 g) and cesium carbonate (2.71 g), followed by heating and stirring at 70° C. for 23 hours. After the reaction mixture was allowed to cool down to room temperature, water (50 mL) was added, and the produced crystals were collected by filtration to give 1.56 g of the title compound (88% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08058474B2 |
|---|
| 出典データセット | uspto-grants-2011_11 |
|---|
| ORD ID | ord-6353beaeb76347d78e7a374d651d132e |
|---|
| 出典メモ | uspto-grants-2011_11 |
|---|
