Aluminum(III) Chloride → HCID 66992305, compound

HRID 557542Notes

Reaction equation

HRID 557542 reaction equation
[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([NH:14]C(OC(C)(C)C)=O)=[CH:11][CH:12]=2)[C:7]([CH3:22])=[CH:6][C:5]1([CH3:24])[CH3:23])(=[O:3])[CH3:2].[Al+3].[Cl-:26].[Cl-].[Cl-]>ClC1C=CC=CC=1>[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([NH2:14])=[CH:11][CH:12]=2)[CH:7]([CH3:22])[CH:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:26])=[CH:10][CH:9]=2)[C:5]1([CH3:23])[CH3:24])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6451240Aluminum(III) ChlorideHCID 11427507HCID 11427507, compound

Product 1

HCID 66992305HCID 66992305, compound

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

A mixture of 1-acetyl-6-(tert-butoxycarbonyl)amino-1,2-dihydro-2,2,4-trimethylquinoline (25 mg) and AlCl3 (35 mg) in chlorobenzene (2 ml) was stirred for 1 h. The reaction mixture was quenched with water and in addition a solution of 2 M NaOH and ethyl acetate were added. The organic layer was separated, dried over MgSO4 and concentrated in vacuo.

Workup

  1. customThe reaction mixture was quenched with water and in addition a solution of 2 M NaOH and ethyl acetate
  2. additionwere added
  3. customThe organic layer was separated
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-09986029e6cb41eb9a63353341568ba3
Source dataset
uspto-grants-2011_11
Patent number
US08058441B2

Reaction notes

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