Fluorobenzene → HCID 17962878, compound

HRID 557543Notes

Reaction equation

HRID 557543 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8]([N:11]1[C:20]2[C:15](=[CH:16][C:17]([NH:21]C(OC(C)(C)C)=O)=[CH:18][CH:19]=2)[C:14]([CH3:29])=[CH:13][C:12]1([CH3:31])[CH3:30])(=[O:10])[CH3:9].[Al+3].[Cl-].[Cl-].[Cl-]>>[C:8]([N:11]1[C:20]2[C:15](=[CH:16][C:17]([NH2:21])=[CH:18][CH:19]=2)[C:14]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)([CH3:29])[CH2:13][C:12]1([CH3:30])[CH3:31])(=[O:10])[CH3:9]

Participants

4

Reactant 3

HCID 10008FluorobenzeneHCID 6451240Aluminum(III) ChlorideHCID 11427507HCID 11427507, compound

Product 1

HCID 17962878HCID 17962878, compound

Procedure

Friedel-Crafts alkylation of fluorobenzene (2 ml) with 1-acetyl-6-(tert-butoxycarbonyl)amino-1,2-dihydro-2,2,4-trimethylquinoline (25 mg) in the presence of AlCl3 (35 mg) was performed according to the method described in example 3.

Sources & evidence

ORD record
ord-a9072711cb934ee1a1697d439ada0f45
Source dataset
uspto-grants-2011_11
Patent number
US08058441B2

Reaction notes

Loading…