反应详情

温度

100 °C

A mixture of 2-bromonaphthalene (41.4 g, 200 mmol), acetyl chloride (11.3 mL, 160 mmol), nitrobenzene (250 mL) and AlCl3 (28 g, 210 mmol) was stirred for 4 hours at 100° C. (oil bath temperature). The resulting reaction mixture was cooled, poured onto ice/water (100 mL) and filtered. The filtrate was washed with water (100 mL). The solvent (nitrobenzene) was removed by distillation. The resulting residue was crystallized from hexane to afford 18 g of desired product (36% yield).

1. customThe resulting reaction mixture
2. temperaturewas cooled
3. additionpoured onto ice/water (100 mL)
4. filtrationfiltered
5. washThe filtrate was washed with water (100 mL)
6. customThe solvent (nitrobenzene) was removed by distillation
7. customThe resulting residue was crystallized from hexane