HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1-Acetyl-6-(bromoacetyl)amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Bromoacetyl chloride | HCID 89602 | — |
| Reactant | 1-(6-amino-2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)ethanone | HCID 2837084 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Acetyl-6-(bromoacetyl)amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline | HCID 17962879 | — |
Reaction Steps
Acylation of 1-acetyl-6-amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (130 mg) with bromoacetyl chloride (69 μl) and N,N-diisopropylethylamine (121 μl) in dichloromethane (10 ml) was performed according to the method described in example 6.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058441B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-24a03b2c7f9c455e9845202d8628217d |
| Source note | uspto-grants-2011_11 |