HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 557568Generated: October 25, 2026
Diisopropylethylamine → 1-Acetyl-6-([2,4-difluorobenzylamino]methylcarbonyl)amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline
https://huagongshe.com/reaction/557568
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,4-Difluorobenzylamine | HCID 2733244 | — |
| Reactant | 1-Acetyl-6-(bromoacetyl)amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline | HCID 17962879 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-Acetyl-6-([2,4-difluorobenzylamino]methylcarbonyl)amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline | HCID 17962913 | — |
Reaction Steps
A mixture of 1-acetyl-6-(bromoacetyl)amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (10 mg), 2,4-difluorobenzylamine (6.0 mg) and N,N-diisopropylethylamine (10 μl) in dioxane (2 ml) was stirred at 40° C. for 18 h. The reaction mixture was concentrated in vacuo. The residue was chromatographed on silicagel in dichloromethane/methanol=1/095/5 (v/v) as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08058441B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-a182c595631942eb81b213c6bc2b4507 |
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| Source note | uspto-grants-2011_11 |
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