HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1-Acetyl-6-(2-[methylthio)ethylamino)carbonyl-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (2-(Methylthio)ethyl)amine | HCID 87697 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 1-Acetyl-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline-6-carboxylic acid | HCID 17962884 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Acetyl-6-(2-[methylthio)ethylamino)carbonyl-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline | HCID 17962925 | — |
Reaction Steps
Condensation of 2-(methylthio)ethylamine (4.1 mg) with 1-acetyl-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline-6-carboxylic acid (10 mg), under the agency of HATU (23 mg) and N,N-diisopropylethylamine (19 μl) in dichloromethane (2 ml) was performed according to the method described in example 11.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058441B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-c3549ca6e7dc474298ad46836022e095 |
| Source note | uspto-grants-2011_11 |