Iodine → 6-ethyl-2,2,4-trimethyl-1,2-dihydroquinoline

HRID 557584Notes

Reaction equation

HRID 557584 reaction equation

[CH2:1]([C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1)[CH3:2].II>O=C(C=C(C)C)C>[CH2:1]([C:3]1[CH:4]=[C:5]2[C:6](=[CH:8][CH:9]=1)[NH:7][C:3]([CH3:9])([CH3:1])[CH:4]=[C:5]2[CH3:6])[CH3:2]

Participants

4

Reactant 2

HCID 115044-Ethylaniline

Product 1

HCID 6593886-ethyl-2,2,4-trimethyl-1,2-dihydroquinoline

Reagents, catalysts & solvents 1

HCID 8858Mesityl oxideSolvent

Procedure

Skraup reaction of p-ethylaniline (1.0 g) and iodine (0.34 g) in mesityl oxide (5 ml) was performed according to the method described in example 1.

Sources & evidence

ORD record: ord-691d1bce717b4ccf93b40e16308aa2d0
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08058441B2

Reaction notes

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