反应详情

Sulfonylation of 1-acetyl-6-(2-hydroxybenzoyl)amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (12 mg) with methylsulfonyl chloride (6.5 μl) was performed in pyridine (1 ml). TLC analysis after stirring for 16 h showed conversion to a higher-running product. The mixture was concentrated, the residue was dissolved in dichloromethane and washed with water. The organic layer was dried (Na2SO4) and concentrated in vacuo. The crude product was purified by silica gel column chromatography. Eluent: heptane/ethyl acetate=8/2 (v/v).

1. concentrationThe mixture was concentrated
2. dissolutionthe residue was dissolved in dichloromethane
3. washwashed with water
4. dry with materialThe organic layer was dried (Na2SO4)
5. concentrationconcentrated in vacuo
6. customThe crude product was purified by silica gel column chromatography