Hydrochloric Acid → HCID 11156384, compound

Participants

Reaction Steps

To a cooled (0° C.) solution of 1-acetyl-4-(4-methoxyphenyl)-6-(4-phenylbenzoyl)amino-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (0.46 g) in CH2Cl2 was added BBr3 under a nitrogen atmosphere. Complete conversion was reached after stirring for 3 h at room temperature. The mixture was cooled, 1 M NaOH was added until basic pH, subsequently ethyl acetate was added and the mixture was acidified with 1 M HCl. The organic layer was separated, dried (MgSO4) and concentrated. The residue was chromatographed on silicagel in heptane/ethyl acetate=1/0→0/1 (v/v) as eluent.

Provenance & Evidence