HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → Methyl acetyl(p-bromobenzoyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 4-Bromobenzoyl chloride | HCID 68515 | — |
| Reactant | Methyl 3-(methylamino)but-2-enoate | HCID 2734182 | — |
| Product | Methyl acetyl(p-bromobenzoyl)acetate | HCID 603116 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
To 3-methylamino-but-2-enoic acid methyl ester (5.0 g, 39.1 mmol) in THF (70 mL) was added pyridine (3.7 mL). The mixture was cooled to 0° C., and 4-bromobenzoyl chloride (8.55 g, 39.1 mmol) in THF (30 mL) was added dropwise over 2 minutes. The reaction was warmed to room temperature over 1 hour and then stirred at room temperature overnight. Aqueous work-up gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058300B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-29ad04ab882743a78678c693c4ae65f6 |
| Source note | uspto-grants-2011_11 |