HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 557625Generated: October 26, 2026
Sulfuric Acid → 1-(Biphenyl-4-yl)cyclopropanecarboxylic acid isopropyl ester
https://huagongshe.com/reaction/557625
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(4-Biphenylyl)cyclopropanecarboxylic acid | HCID 21552263 | — |
| Product | 1-(Biphenyl-4-yl)cyclopropanecarboxylic acid isopropyl ester | HCID 66660208 | — |
Reaction Steps
1-(Biphenyl-4-yl)cyclopropanecarboxylic acid (10 g, 42 mmol), isopropanol (100 mL), thionyl chloride (6.8 mL, 92 mmol) were heated to 65° C. for 4 hours. Sulfuric acid (20 mL) was added and heated at 65° C. overnight. The product is extracted with CH2Cl2 and water (2×) dried and evaporated to yield 10.8 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08058300B2 |
|---|
| Source dataset | uspto-grants-2011_11 |
|---|
| ORD ID | ord-5bf0e7f0cc054736ba00f2d13d6ff1d3 |
|---|
| Source note | uspto-grants-2011_11 |
|---|
