(2S)-2-amino-2-cyclopentylacetic acid → (S)-2-Cyclopentyl-2-((methoxycarbonyl)amino)acetic acid

HRID 55764Notes

Reaction equation

HRID 55764 reaction equation
[CH3:1][O:2][C:3]([NH:5][C@H:6]([C:10]([OH:12])=[O:11])[CH:7]([CH3:9])[CH3:8])=[O:4].N[C@@H:14](C1CCCC1)[C:15](O)=O>>[CH:7]1([C@H:6]([NH:5][C:3]([O:2][CH3:1])=[O:4])[C:10]([OH:12])=[O:11])[CH2:9][CH2:15][CH2:14][CH2:8]1

Participants

3

Reactant 2

HCID 10374564(2S)-2-amino-2-cyclopentylacetic acidHCID 10942966(2S)-2-((methoxycarbonyl)amino)-3-methylbutanoic acid

Product 1

HCID 66630234(S)-2-Cyclopentyl-2-((methoxycarbonyl)amino)acetic acid

Procedure

(S)-2-cyclopentyl-2-(methoxycarbonylamino)acetic acid was synthesized similar to N-methoxycarbonyl-L-Valine, using (S)-2-amino-2-cyclopentylacetic acid instead of L-Valine.

Sources & evidence

ORD record
ord-1607377b6be24c68893b981f96585083
Source dataset
uspto-grants-2016_09
Patent number
US09433609B2

Reaction notes

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