Ethyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylate → HCID 66660022, compound

HRID 557655Notes

Reaction equation

HRID 557655 reaction equation
[CH:1]1([C@H:5]([O:7][C:8](=[O:23])[NH:9][C:10]2[C:11]([CH3:22])=[N:12][O:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18](Br)=[CH:17][CH:16]=2)[CH3:6])[CH2:4][CH2:3][CH2:2]1.[CH2:24]([O:26][C:27]([C:29]1([C:32]2[CH:37]=[CH:36][C:35](B3OC(C)(C)C(C)(C)O3)=[CH:34][CH:33]=2)[CH2:31][CH2:30]1)=[O:28])[CH3:25]>>[CH2:24]([O:26][C:27]([C:29]1([C:32]2[CH:37]=[CH:36][C:35]([C:18]3[CH:19]=[CH:20][C:15]([C:14]4[O:13][N:12]=[C:11]([CH3:22])[C:10]=4[NH:9][C:8]([O:7][C@@H:5]([CH:1]4[CH2:4][CH2:3][CH2:2]4)[CH3:6])=[O:23])=[CH:16][CH:17]=3)=[CH:34][CH:33]=2)[CH2:30][CH2:31]1)=[O:28])[CH3:25]

Participants

3

Reactant 2

HCID 53217182Ethyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylateHCID 66660618HCID 66660618, compound

Product 1

HCID 66660022HCID 66660022, compound

Procedure

Prepared according to the procedure described in Example 1, Step 6 using [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-carbamic acid (R)-1-cyclobutyl-ethyl ester and 1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-07dd8b7900514aa7a212d305db53244d
Source dataset
uspto-grants-2011_11
Patent number
US08058300B2

Reaction notes

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