Ethyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylate → HCID 66660665, compound

HRID 557665Notes

Reaction equation

HRID 557665 reaction equation
[C:1]([Si:5]([CH3:33])([CH3:32])[O:6][C:7]1[CH:8]=[C:9]([CH:13]([O:15][C:16](=[O:31])[NH:17][C:18]2[C:19]([CH3:30])=[N:20][O:21][C:22]=2[C:23]2[CH:28]=[CH:27][C:26](Br)=[CH:25][CH:24]=2)[CH3:14])[CH:10]=[CH:11][CH:12]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:34]([O:36][C:37]([C:39]1([C:42]2[CH:47]=[CH:46][C:45](B3OC(C)(C)C(C)(C)O3)=[CH:44][CH:43]=2)[CH2:41][CH2:40]1)=[O:38])[CH3:35]>>[CH2:34]([O:36][C:37]([C:39]1([C:42]2[CH:47]=[CH:46][C:45]([C:26]3[CH:27]=[CH:28][C:23]([C:22]4[O:21][N:20]=[C:19]([CH3:30])[C:18]=4[NH:17][C:16]([O:15][CH:13]([C:9]4[CH:10]=[CH:11][CH:12]=[C:7]([O:6][Si:5]([C:1]([CH3:4])([CH3:3])[CH3:2])([CH3:33])[CH3:32])[CH:8]=4)[CH3:14])=[O:31])=[CH:24][CH:25]=3)=[CH:44][CH:43]=2)[CH2:40][CH2:41]1)=[O:38])[CH3:35]

Participants

3

Reactant 2

HCID 53217182Ethyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylateHCID 66660557HCID 66660557, compound

Product 1

HCID 66660665HCID 66660665, compound

Procedure

Prepared according to the procedure described in Example 1, Step 6 using [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-carbamic acid 1-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethyl ester and 1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a4ff0209d7b34d83be9904705b2b0b54
Source dataset
uspto-grants-2011_11
Patent number
US08058300B2

Reaction notes

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