HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 557673Generated: October 26, 2026
Hydrochloric Acid → 1-(3,5-Dibromophenyl)ethanone
https://huagongshe.com/reaction/557673
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Benzoic acid, 3,5-dibromo- | HCID 12063 | — |
| Reactant | HCID 178418348 | HCID 178418348 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-(3,5-Dibromophenyl)ethanone | HCID 621825 | — |
Reaction Steps
To a solution of 3,5-dibromobenzoic acid (2.5 g, 8.9 mmol) in Et2O (30 mL) at 0° C. was added methyllithium (1.6M in Et2O; 12.3 mL, 19.6 mmol) dropwise. The reaction was stirred at 0° C. for 2 hours, and then worked-up with EtOAc and 10% aqueous HCl. The crude material was purified by silica gel chromatography to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08058300B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-39c48f6d7e864b28b0186d9de9d4f0ef |
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| Source note | uspto-grants-2011_11 |
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