1-(4-Boronophenyl)cyclopropane-1-carboxylic acid → 1-{4'-[4-((R)-1-Phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

HRID 557684Notes

Reaction equation

HRID 557684 reaction equation
[C:1]1([C@H:7]([O:9][C:10](=[O:24])[NH:11][C:12]2[CH:13]=[N:14][O:15][C:16]=2[C:17]2[CH:22]=[CH:21][C:20](Br)=[CH:19][CH:18]=2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:25]([C:28]1([C:31]2[CH:36]=[CH:35][C:34](B(O)O)=[CH:33][CH:32]=2)[CH2:30][CH2:29]1)([OH:27])=[O:26]>>[C:1]1([C@H:7]([O:9][C:10]([NH:11][C:12]2[CH:13]=[N:14][O:15][C:16]=2[C:17]2[CH:22]=[CH:21][C:20]([C:34]3[CH:35]=[CH:36][C:31]([C:28]4([C:25]([OH:27])=[O:26])[CH2:30][CH2:29]4)=[CH:32][CH:33]=3)=[CH:19][CH:18]=2)=[O:24])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 467396661-(4-Boronophenyl)cyclopropane-1-carboxylic acidHCID 66660307[5-(4-bromo-phenyl)-isoxazol-4-yl]-carbamic acid (R)-1-phenyl-ethyl ester

Product 1

HCID 498389331-{4'-[4-((R)-1-Phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Procedure

Prepared according to the procedure described in Example 1, Step 6 using [5-(4-bromo-phenyl)-isoxazol-4-yl]-carbamic acid (R)-1-phenyl-ethyl ester and 4-(1-carboxycyclopropyl)phenylboronic acid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-533c683f670247679da38f4faee7b7f9
Source dataset
uspto-grants-2011_11
Patent number
US08058300B2

Reaction notes

Loading…