HuagongsheHuagongshe Chemistry Print Report · For research reference only
1'-benzyl-3H-spiro[2-benzofuran-1,3'-pyrrolidine] → 3H-Spiro[2-benzofuran-1,3'-pyrrolidine]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1'-benzyl-3H-spiro[2-benzofuran-1,3'-pyrrolidine] | HCID 66661782 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3H-Spiro[2-benzofuran-1,3'-pyrrolidine] | HCID 22012187 | 92% |
Reaction Steps
To a solution of 1′-benzyl-3H-spiro[2-benzofuran-1,3′-pyrrolidine] (200 mg, 0.0008 mol) in methanol (10 mL) was added Pd/C (150 mg), and the suspension was hydrogenated under H2 (50 psi) overnight. The mixture was filtered and then concentrated to give the desired compound (110 mg, 92% yield). MS (ESI): 176.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058288B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-86c5dc467b4042e78f2c2123477bbd9c |
| Source note | uspto-grants-2011_11 |